Developing Iron management polymers for treating disease

Fe Pharmaceuticals was founded to develop unique, purpose-designed, iron management polymers as therapeutic treatments to alter the course of serious diseases in patients.

Iron is crucial to life

Iron Binding Polymers

Fe Pharmaceuticals was founded to develop unique, purpose-designed, iron management polymers as therapeutic treatments to alter the course of serious diseases in patients.

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Denying Iron to Bacterial Infections

DIBI (Denying Iron to Bacterial Infections) is a polymer built to bind iron tighter than any pathogen molecules. Each molecule of DIBI to bind three iron molecules completely.

Treating Infectious Diseases

DIBI can be used to treat infectious diseases by removing the iron that pathogens need to grow, starving them.

Iron is required for human life

life-essential processes utilize iron (within enzymes)
proper level maintained for health (4-5g)

Iron required for pathogens too

from parasites to fungi to bacteria viruses

Pathogens must get iron from host

many have specialized iron obtaining molecules, siderophores
only a small amount of body iron (0.1%; 2-4mg) is available to most pathogens

Biological tug-of-war between body and pathogens over available iron

too much free iron favors
pathogens
natural body iron withdrawal mechanism: hypoferremic response, reduces free iron

Biological tug-of-war between body and pathogens over available iron

too much free iron favors
pathogens
natural body iron withdrawal mechanism: hypoferremic response, reduces free iron

Biological tug-of-war between body and pathogens over available iron

too much free iron favors
pathogens
natural body iron withdrawal mechanism: hypoferremic response, reduces free iron